What Is Hesperidin (520-26-3)?
Hesperidin is Hesperetin 7-O-rutinoside, a natural plant compound with CAS number 520-26-3. It appears as off-white to pale yellow fine powder, odorless with a slightly bitter taste and is one of the most studied botanical actives in the global plant extract market.
Hesperidin is a flavanone rutinoside — the 7-O-rutinoside of hesperetin. It is the main flavonoid in sweet orange peel, accounting for up to 4-7% of the dried peel weight. After enzymatic hydrolysis it yields the aglycone hesperetin, which has stronger antioxidant activity.
In the dietary supplement industry hesperidin is widely used for vascular and capillary health, often combined with vitamin C and diosmin. The famous "Diosmin + Hesperidin" combination (500 mg / 150 mg) is one of the most prescribed phlebotonic formulas in Europe.
Key Properties of Hesperidin
| Property | Specification |
|---|---|
| Product Name | Hesperidin |
| CAS Number | 520-26-3 |
| Chemical Name | Hesperetin 7-O-rutinoside |
| Appearance | Off-white to pale yellow fine powder, odorless with a slightly bitter taste |
| Purity | ≥95% (HPLC) |
| Melting Point | Approx. 250-252 °C (decomposes) |
| Solubility | Very low solubility in cold water; soluble in hot water and dilute alkali; soluble in DMSO and pyridine |
| Natural Sources | Sweet orange (Citrus sinensis) peel; Mandarin (Citrus reticulata) peel; Lemon (Citrus limon) peel |
Sources & Extraction
Hesperidin is naturally found in Sweet orange (Citrus sinensis) peel, Mandarin (Citrus reticulata) peel and Lemon (Citrus limon) peel. ZHII extracts hesperidin from the most abundant commercial source, ensuring consistent purity and supply.
ZHII extracts hesperidin from sweet orange (Citrus sinensis) peel — the main by-product of the citrus juice industry. The peel is dried, milled, extracted with food-grade ethanol, and the crude extract is refined by alkali dissolution and acid precipitation to yield crystalline hesperidin of ≥95% HPLC purity.
Applications of Hesperidin
Few botanical actives cross industry boundaries as easily as hesperidin:
Dietary Supplements
Vascular and capillary health capsules and tablets; commonly combined with diosmin (90:10 ratio) for chronic venous insufficiency support.
Cosmetics & Personal Care
Antioxidant and capillary-support active in eye creams, anti-redness serums and after-sun formulations.
Food Fortification
Added to functional beverages, fortified juices and antioxidant drink mixes; also used as a natural color protectant.
Pharmaceutical Research
A standard reference compound in flavonoid bioavailability studies and a key starting material for semi-synthetic diosmin production.
Recommended Use & Dosage
In dietary supplements 500 mg hesperidin per day is typical, often combined with 50-100 mg diosmin. In cosmetic formulations 0.5-2.0% in creams and serums.
Packaging & Storage
1 kg aluminum foil bags, 5 kg food-grade plastic pails and 25 kg fibre drums with PE liner. Store in a cool, dry place protected from light.. Store in a cool, dry place away from direct sunlight, tightly sealed to protect from moisture. When stored properly, the product remains stable for at least 24 months from the production date.
Why Source Hesperidin from ZHII?
- Factory-direct supply — we manufacture and export plant extracts from Xi’an, China, with competitive pricing and stable long-term stock.
- Certified quality — ISO9001 and ISO14001 certified production; KOSHER and HALAL certified products; a Certificate of Analysis accompanies every batch.
- Global experience — customers in more than 50 countries across the EU, the Americas and Asia trust ZHII as their plant extract supplier.
- Flexible quantities — from free evaluation samples and small trial packs to full container loads.
- Technical support — our team provides formulation guidance, regulatory documents and application advice.
Frequently Asked Questions
What is the difference between hesperidin and hesperetin?
Hesperidin is the rutinoside glycoside (hesperetin 7-O-rutinoside); hesperetin is the aglycone obtained after removal of the rutinose sugar. Hesperidin is the natural form found in citrus peel; hesperetin is more bioactive and is produced industrially by enzymatic hydrolysis of hesperidin.
What is the typical use of hesperidin + diosmin?
The 90:10 diosmin/hesperidin combination (often 500 mg diosmin + 50 mg hesperidin per tablet) is a well-established phlebotonic formulation for chronic venous insufficiency and hemorrhoid symptom relief, widely used in European pharmacy.
Does ZHII supply water-soluble hesperidin?
Standard hesperidin has low water solubility. For water-dispersible applications we supply hesperidin methyl chalcone and hydroxypropyl-beta-cyclodextrin complexed hesperidin. Contact our team for the right grade for your formulation.
Get a Free Sample of Hesperidin
Looking for a reliable Hesperidin manufacturer and supplier? ZHII offers high-purity Hesperidin (520-26-3) with fast worldwide delivery and free samples. Visit our plant extract catalog to explore the full botanical extract range, or contact us today by email at sxzhiyi@126.com or WhatsApp +86 151 0299 2009 for a quotation within 24 hours.