What Is Apigenin (520-36-5)?
Apigenin is 4′,5,7-Trihydroxyflavone, a natural plant compound with CAS number 520-36-5. It appears as pale yellow to yellow crystalline powder, almost odorless and is one of the most studied botanical actives in the global plant extract market.
Apigenin belongs to the flavone subclass of flavonoids, structurally a 4′,5,7-trihydroxyflavone. It is the aglycone of apigenin-7-glucoside (apigetrin), the main flavonoid in chamomile tea. After enzymatic hydrolysis, apigetrin yields apigenin aglycone.
In dietary supplements apigenin is used at 50-100 mg per day, often in sleep and relaxation formulations. It is a selective benzodiazepine-binding-site ligand, supporting its traditional use in chamomile tea for evening relaxation.
Key Properties of Apigenin
| Property | Specification |
|---|---|
| Product Name | Apigenin |
| CAS Number | 520-36-5 |
| Chemical Name | 4′,5,7-Trihydroxyflavone |
| Appearance | Pale yellow to yellow crystalline powder, almost odorless |
| Purity | ≥98% (HPLC) |
| Melting Point | Approx. 345-350 °C (decomposes) |
| Solubility | Practically insoluble in water; soluble in ethanol, DMSO and dilute alkali |
| Natural Sources | Chamomile (Matricaria chamomilla) flower; Parsley (Petroselinum crispum); Celery (Apium graveolens) seed; Grapefruit (Citrus paradisi) |
Sources & Extraction
Apigenin is naturally found in Chamomile (Matricaria chamomilla) flower, Parsley (Petroselinum crispum), Celery (Apium graveolens) seed and Grapefruit (Citrus paradisi). ZHII extracts apigenin from the most abundant commercial source, ensuring consistent purity and supply.
ZHII extracts apigenin from dried chamomile (Matricaria chamomilla) flower, which contains 0.3-0.8% apigenin and apigenin-7-glucoside. The extraction uses food-grade ethanol, followed by enzymatic hydrolysis of the glycoside, crystallization and HPLC-controlled purification to deliver ≥98% HPLC apigenin.
Applications of Apigenin
Few botanical actives cross industry boundaries as easily as apigenin:
Dietary Supplements
Sleep, relaxation and stress-management formulas; commonly combined with L-theanine, magnesium and chamomile extract.
Cosmetics & Personal Care
Soothing active in after-sun, anti-redness and sensitive-skin formulations; supports skin barrier and oxidative defense.
Functional Beverage
Added to calming herbal teas, evening functional drinks and sleep-support beverage formulas.
Pharmaceutical Research
A widely used reference compound in flavonoid pharmacology and chemoprevention research.
Recommended Use & Dosage
In dietary supplements 50-100 mg per day is typical for relaxation support. In cosmetic formulations 0.1-0.5% in creams and serums.
Packaging & Storage
1 kg aluminum foil bags with double PE liner, 5 kg plastic pails and 25 kg fibre drums.. Store in a cool, dry place away from direct sunlight, tightly sealed to protect from moisture. When stored properly, the product remains stable for at least 24 months from the production date.
Why Source Apigenin from ZHII?
- Factory-direct supply — we manufacture and export plant extracts from Xi’an, China, with competitive pricing and stable long-term stock.
- Certified quality — ISO9001 and ISO14001 certified production; KOSHER and HALAL certified products; a Certificate of Analysis accompanies every batch.
- Global experience — customers in more than 50 countries across the EU, the Americas and Asia trust ZHII as their plant extract supplier.
- Flexible quantities — from free evaluation samples and small trial packs to full container loads.
- Technical support — our team provides formulation guidance, regulatory documents and application advice.
Frequently Asked Questions
What is the difference between apigenin and apigetrin?
Apigenin is the aglycone; apigetrin (apigenin-7-glucoside) is the naturally occurring glucose-bound form found in chamomile. Industrial apigenin is typically produced by enzymatic hydrolysis of apigetrin.
Is apigenin safe for long-term use?
Yes. Apigenin has a long history of safe consumption via chamomile tea. At supplement doses of 50-100 mg per day it is generally well tolerated. Always follow product-specific dosage recommendations and consult a healthcare provider for long-term use.
Does ZHII supply apigenin from chamomile?
Yes. Our standard apigenin is extracted from chamomile flower (Matricaria chamomilla) and verified by HPLC, IR and microbial testing. We also offer apigenin from parsley and celery sources on request.
Get a Free Sample of Apigenin
Looking for a reliable Apigenin manufacturer and supplier? ZHII offers high-purity Apigenin (520-36-5) with fast worldwide delivery and free samples. Visit our plant extract catalog to explore the full botanical extract range, or contact us today by email at sxzhiyi@126.com or WhatsApp +86 151 0299 2009 for a quotation within 24 hours.