What Is (-)-Caryophyllene Oxide (1139-30-6)?
(-)-Caryophyllene Oxide is (-)-Caryophyllene 4,5-endoperoxide, a natural plant compound with CAS number 1139-30-6. It appears as white crystalline powder with a faint woody, cedar-like aroma and is one of the most studied botanical actives in the global plant extract market.
Chemically it is a tricyclic sesquiterpene with a 4,5-endoperoxide bridge, formed in plants by enzymatic oxidation of beta-caryophyllene. The (-) enantiomer is the natural form isolated from clove, pepper and hemp; the (+) form is essentially absent in nature and is only obtained by asymmetric synthesis.
In the essential oil industry (-)-caryophyllene oxide is appreciated for its dry, woody, cedar-like odor that blends well with floral and citrus accords. It also functions as a fixative, slowing the evaporation of more volatile top notes.
Key Properties of (-)-Caryophyllene Oxide
| Property | Specification |
|---|---|
| Product Name | (-)-Caryophyllene Oxide |
| CAS Number | 1139-30-6 |
| Chemical Name | (-)-Caryophyllene 4,5-endoperoxide |
| Appearance | White crystalline powder with a faint woody, cedar-like aroma |
| Purity | ≥90% (GC) — typical, COA available |
| Melting Point | Approx. 61-63 °C |
| Solubility | Freely soluble in ethanol, ethyl acetate and fixed essential oils; very low solubility in water |
| Natural Sources | Clove (Syzygium aromaticum) buds and stems; Black pepper (Piper nigrum) berries; Hemp (Cannabis sativa) aerial parts; Cinnamon (Cinnamomum verum) bark |
Sources & Extraction
(-)-Caryophyllene Oxide is naturally found in Clove (Syzygium aromaticum) buds and stems, Black pepper (Piper nigrum) berries, Hemp (Cannabis sativa) aerial parts and Cinnamon (Cinnamomum verum) bark. ZHII extracts (-)-caryophyllene oxide from the most abundant commercial source, ensuring consistent purity and supply.
The product is obtained by fractional distillation and crystallization of clove stem or leaf oil, followed by mild oxidation of the beta-caryophyllene fraction. ZHII uses food-grade ethanol as the crystallization solvent and verifies the final enantiomeric purity by chiral GC.
Applications of (-)-Caryophyllene Oxide
Few botanical actives cross industry boundaries as easily as (-)-caryophyllene oxide:
Fragrance & Perfumery
A premium woody-amber base note for fine fragrances, soaps and diffusers; works as a fixative to extend the life of citrus and floral top notes.
Flavor Formulations
Used in trace amounts in spice and balsamic flavor bases for beverages, confectionery and savory seasonings, where it adds depth without dominating the profile.
Botanical Extracts & Tinctures
A quality marker for clove, pepper and hemp extracts; standardized caryophyllene oxide content is widely used in product specification sheets.
Agricultural & Material Research
Studied as a naturally derived antifungal and termiticidal agent for low-toxicity crop protection and wood preservation research.
Recommended Use & Dosage
In flavor systems typical use levels are below 50 ppm in the finished product. In fragrance applications it is generally used at 1-5% of the fragrance concentrate. Contact our technical team for application-specific recommendations.
Packaging & Storage
Supplied in 1 kg aluminum foil bags, 5 kg food-grade plastic pails and 25 kg fibre drums. Custom packaging is available on request.. Store in a cool, dry place away from direct sunlight, tightly sealed to protect from moisture. When stored properly, the product remains stable for at least 24 months from the production date.
Why Source (-)-Caryophyllene Oxide from ZHII?
- Factory-direct supply — we manufacture and export plant extracts from Xi’an, China, with competitive pricing and stable long-term stock.
- Certified quality — ISO9001 and ISO14001 certified production; KOSHER and HALAL certified products; a Certificate of Analysis accompanies every batch.
- Global experience — customers in more than 50 countries across the EU, the Americas and Asia trust ZHII as their plant extract supplier.
- Flexible quantities — from free evaluation samples and small trial packs to full container loads.
- Technical support — our team provides formulation guidance, regulatory documents and application advice.
Frequently Asked Questions
What is the difference between caryophyllene and caryophyllene oxide?
Caryophyllene (CAS 87-44-5) is the parent sesquiterpene hydrocarbon, while caryophyllene oxide (CAS 1139-30-6) is its naturally occurring endoperoxide — the oxidized form, with a dry woody aroma instead of the spicy-peppery odor of the parent compound.
Is (-)-caryophyllene oxide natural?
Yes. The (-) enantiomer is the form produced by plants such as clove, black pepper and hemp, and is the only form obtained from natural extraction. ZHII supplies 100% naturally sourced (-)-caryophyllene oxide.
Does ZHII supply (-)-caryophyllene oxide with COA?
Yes. Every batch ships with a Certificate of Analysis showing GC purity, chiral purity, heavy metals, microbial count and moisture. ISO9001/ISO14001 production and KOSHER/HALAL certificates are available on request.
Get a Free Sample of (-)-Caryophyllene Oxide
Looking for a reliable (-)-Caryophyllene Oxide manufacturer and supplier? ZHII offers high-purity (-)-Caryophyllene Oxide (1139-30-6) with fast worldwide delivery and free samples. Visit our plant extract catalog to explore the full botanical extract range, or contact us today by email at sxzhiyi@126.com or WhatsApp +86 151 0299 2009 for a quotation within 24 hours.