What Is Hesperetin (520-33-2)?
Hesperetin is (2S)-3′,5,7-Trihydroxy-4′-methoxyflavanone, a natural plant compound with CAS number 520-33-2. It appears as pale yellow to light brown fine powder, almost odorless with a mild bitter taste and is one of the most studied botanical actives in the global plant extract market.
Hesperetin is a flavanone — the 4′-O-methylated analog of eriodictyol. It is the aglycone obtained after removal of the rutinose sugar from hesperidin. Compared to hesperidin, hesperetin is more lipophilic and shows stronger in-vitro antioxidant activity.
In dietary supplements hesperetin is used at 100-300 mg per day, often in metabolic health and antioxidant formulas. It is also a popular ingredient in anti-aging and skin-brightening cosmetic formulations, where it supports collagen synthesis and skin barrier function.
Key Properties of Hesperetin
| Property | Specification |
|---|---|
| Product Name | Hesperetin |
| CAS Number | 520-33-2 |
| Chemical Name | (2S)-3′,5,7-Trihydroxy-4′-methoxyflavanone |
| Appearance | Pale yellow to light brown fine powder, almost odorless with a mild bitter taste |
| Purity | ≥98% (HPLC) |
| Melting Point | Approx. 224-226 °C |
| Solubility | Practically insoluble in water; soluble in ethanol, DMSO and dilute alkali |
| Natural Sources | Sweet orange (Citrus sinensis) peel — as hesperidin aglycone; Mandarin (Citrus reticulata) peel; Lemon (Citrus limon) peel |
Sources & Extraction
Hesperetin is naturally found in Sweet orange (Citrus sinensis) peel — as hesperidin aglycone, Mandarin (Citrus reticulata) peel and Lemon (Citrus limon) peel. ZHII extracts hesperetin from the most abundant commercial source, ensuring consistent purity and supply.
ZHII produces hesperetin by enzymatic hydrolysis of high-purity hesperidin extracted from sweet orange peel. The hesperidin is treated with a food-grade rutinosidase enzyme (naringinase), then the released aglycone is crystallized and purified by HPLC-controlled methods to ≥98% purity.
Applications of Hesperetin
Few botanical actives cross industry boundaries as easily as hesperetin:
Dietary Supplements
Antioxidant and metabolic health capsules; commonly combined with hesperidin, vitamin C and diosmin.
Cosmetics & Personal Care
Anti-aging and skin-brightening active in face creams, eye serums and after-sun formulations.
Functional Food & Beverage
Added to antioxidant functional drinks and fortified citrus beverages.
Pharmaceutical Research
A reference compound in flavonoid bioavailability and citrus flavonoid pharmacology research.
Recommended Use & Dosage
In dietary supplements 100-300 mg per day is typical. In cosmetic formulations 0.5-1.5% in creams and serums.
Packaging & Storage
1 kg aluminum foil bags with double PE liner, 5 kg plastic pails and 25 kg fibre drums.. Store in a cool, dry place away from direct sunlight, tightly sealed to protect from moisture. When stored properly, the product remains stable for at least 24 months from the production date.
Why Source Hesperetin from ZHII?
- Factory-direct supply — we manufacture and export plant extracts from Xi’an, China, with competitive pricing and stable long-term stock.
- Certified quality — ISO9001 and ISO14001 certified production; KOSHER and HALAL certified products; a Certificate of Analysis accompanies every batch.
- Global experience — customers in more than 50 countries across the EU, the Americas and Asia trust ZHII as their plant extract supplier.
- Flexible quantities — from free evaluation samples and small trial packs to full container loads.
- Technical support — our team provides formulation guidance, regulatory documents and application advice.
Frequently Asked Questions
What is the difference between hesperetin and hesperidin?
Hesperidin is the rutinoside glycoside found naturally in citrus peel; hesperetin is the aglycone obtained after enzymatic hydrolysis of hesperidin. Hesperetin is more bioactive and more lipophilic; hesperidin is more water-soluble and the natural form.
Is hesperetin better than hesperidin for supplementation?
Hesperetin shows stronger in-vitro antioxidant activity, but hesperidin is better absorbed in the small intestine (after gut microbiota hydrolysis to hesperetin). The choice depends on the formulation goal: hesperetin for fast-acting antioxidant claims; hesperidin for sustained-release and natural-source claims.
Does ZHII supply other citrus flavonoids?
Yes. We supply the full citrus flavonoid family: hesperidin, hesperetin, naringin, naringenin, neohesperidin, neohesperidin dihydrochalcone (NHDC), and diosmin. Contact our team for the right grade for your formulation.
Get a Free Sample of Hesperetin
Looking for a reliable Hesperetin manufacturer and supplier? ZHII offers high-purity Hesperetin (520-33-2) with fast worldwide delivery and free samples. Visit our plant extract catalog to explore the full botanical extract range, or contact us today by email at sxzhiyi@126.com or WhatsApp +86 151 0299 2009 for a quotation within 24 hours.